منابع مشابه
About the design of oligo-chips
On a very small surface, a chip, several thousands of oligonucleotides, having a length between 20 and 25 bases, can be synthesized. The actual technology to manufacture in parallel these high density oligo-chips is photolithography using masks to select the oligos on which one base, among A, T, G or C, must be added. The problems tackled here deal with the possibility, with a unique series of ...
متن کاملPicky: oligo microarray design for large genomes
MOTIVATION Many large genomes are getting sequenced nowadays. Biologists are eager to start microarray analysis taking advantage of all known genes of a species, but existing microarray design tools were very inefficient for large genomes. Also, many existing tools operate in a batch mode that does not assure best designs. RESULTS Picky is an efficient oligo microarray design tool for large g...
متن کاملComputational Antisense Oligo Prediction with a Neural Network
Motivation: The expression of a gene can be selectively inhibited by antisense oligonucleotides (AOs) targeting the mRNA. However, if the target site in the mRNA is picked randomly, typically 20% or less of the AOs are effective inhibitors in vivo. The sequence properties that make an AO effective are not well understood, thus many AOs need to be tested to find good inhibitors, which is time co...
متن کاملComputational antisense oligo prediction with a neural network model
MOTIVATION The expression of a gene can be selectively inhibited by antisense oligonucleotides (AOs) targeting the mRNA. However, if the target site in the mRNA is picked randomly, typically 20% or less of the AOs are effective inhibitors in vivo. The sequence properties that make an AO effective are not well understood, thus many AOs need to be tested to find good inhibitors, which is time con...
متن کاملQuality Control in Manufacturing Oligo Arrays: A Combinatorial Design Approach
The advent of the DNA microarray technology has brought with it the exciting possibility of simultaneously observing the expression levels of all genes in an organism. One such microarray technology, called "oligo arrays," manufactures short single strands of DNA (called probes) onto a glass surface using photolithography. An altered or missed step in such a manufacturing protocol can adversely...
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ژورنال
عنوان ژورنال: Journal of Chemical Sciences
سال: 2016
ISSN: 0974-3626,0973-7103
DOI: 10.1007/s12039-016-1157-2